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Image Search Results
Journal: Cancers
Article Title: Chemosensitivity of Patient-Derived Cancer Stem Cells Identifies Colorectal Cancer Patients with Potential Benefit from FGFR Inhibitor Therapy
doi: 10.3390/cancers12082010
Figure Lengend Snippet: Little association between FGFR inhibitor sensitivity and FGFR gene alterations, or mRNA levels in colorectal cancer spheroids. ( A ), Copy numbers of the FGF9 , and FGFR1–4 gene loci in six colon cancer TIC-spheroid lines (HC1T, HC6T, HC9T, H11T, HC20T, and HC73T). Gain (blue) or loss (red) of the chromosomal region was determined relative to the normal epithelial genomic DNA (2.0). “R” stands for “responsive” and “NR” for “non-responsive” to erdafitinib in culture. ( B ) The FGFR mRNA expression levels in all 25 TIC-spheroid lines and three normal colonic epithelial stem cell lines (HC6N, HC9N, and HC20N) as determined by RNA-seq analysis (see Materials and Methods). TPM; transcripts per million in the RNA-seq samples. ( C ) Association between GEI and TPM in 25 colorectal cancer spheroid lines. There was a weak tendency between sensitivity to erdafitinib and FGFR3/4 mRNA expression ( r = −0.21, r = −0.20, respectively).
Article Snippet:
Techniques: Expressing, RNA Sequencing